Please read the product info of all your drugs or ask your pharmacist. Prednisone causes so many side effects, like weight gain, Cushing's syndrome, moon face, high blood sugar, osteoporosis, weakness, fatigue,edema, excessive hair growth, skin discoloration and turgidity. Summary. Red face is found among people who take Prednisone, especially for people who are female, 60+ old , have been taking the drug for 1 month, also take medication Remicade, and have Crohn's disease. Cari, I can totally understand abut and his red face. For two years, before the high dose of Prednisone my face looked like a tomato. At the time my daughter was in the 5th grade. 3 weeks ago my doctor put me on a prednisone dose pak and also injected prednisone into my body. A week later I developed a rash on my right side of my face and all the way down my chest. Careful, Tenille- I have had that exact same reaction to several drugs- sulphur and erythromycin. It WAS an allergic reaction in my case. My whole body was covered in the worst sunburn of my life- without sun exposure & I even got a high fever. Side Effects. Drug information provided by: IBM Micromedex. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Her reaction was fairly strong, her face was flaming red and felt like it was on fire. Dr. said they would likely avoid having her take it in the future unless it was absolutely necessary. They didn't seem to think that her reaction to it would get any worse or threaten her health but since she seemed to be so sensitive to it, they said they would avoid it in the future if at all possible. Prednisone suppresses immune reactions, and the allergic reaction subsides. Patients should take precautions and avoid the allergens that caused the reaction. Patients should take precautions and avoid the allergens that caused the reaction. About a week into taking the prednisone, I developed a very hot and burning face and neck. I have been off the prednisone for 2 days but am still experiencing the symptoms. My face turns a little red-- I look a little flushed. My skin feels hot to the touch on my face and has a burning hot sensation. Find information about common, infrequent and rare side effects of Prednisone Oral.